Move oven rack to middle position and preheat to 350 degrees F. Lightly grease a 9x13-inch baking dish with nonstick cooking spray.

Cook spaghetti according to package directions.

Cook ground beef in a large skillet until completely browned. Drain off the fat, and then stir in onion powder, garlic powder, Italian seasoning, and pasta sauce.

In a large heat-proof bowl, whisk together melted butter, eggs, and Parmesan cheese.

Once the spaghetti is done cooking, drain, and add spaghetti to the butter and egg mixture. Toss spaghetti until evenly coated.

Place half of the spaghetti into the bottom of the prepared baking dish. Evenly distribute half of the cottage cheese on top, then half of the meat mixture, followed by half of the shredded mozzarella cheese.

Repeat the layers and cover the baking dish with foil.

Bake for 30 minutes, and then uncover, rotate the pan, and bake 8-10 minutes longer, or until cheese is melted.